- Open The original photo into Photoshop [1261px X 1546px]

- From Tools Select Crop Tool (c)
- From the Crop Tools Properties bar Set the Width 800px And Height 600px or other custom value you want

- Drag into image the area you want to Crop with fixed size 800x600px

- Press Enter and Crop

- And here the new size of image.

- Save the document with new filename